Dosage and quality control are key, and Prohibition militate...

Raison d'État

npub1mts2l7rsvgpqxdc8sk39e50fpntw0p7eamq8pp3kek5h6k7qemzq83ueyt

hex

0000508591ef5896b14c2898b03adb8754581dc3139a84bdf6714afe39914512

nevent

nevent1qqsqqqzsskg77kykk9xz3x9s8tdcw4zcrhp38x5yhhm8zjh78xg52ysprpmhxue69uhhyetvv9ujuem4d36kwatvw5hx6mm9qgsd4c90lpcxyqsrxurctgju685se4h8slv7asrsscmvm2tat0qva3qpa2gw7

Kind-1 (TextNote)

2026-03-27T05:15:16Z

↳ Reply to Cyph3rp9nk (npub1lnms53w04qt742qnhxag5d6awy7nz6055flnmjkr6jg39hm86dlq7arrnt)

While I’m in favor of the free trade of drugs, be careful. In a couple of days, you’ll see how “fun” that mild depression caused by MDMA really is—an...

Dosage and quality control are key, and Prohibition militates against both.

I've had MDMA maybe ten times in my life, never once experienced the crash.

Dodgy suppliers mix dopaminergics in with the MDMA because its cheaper and gives the effect the market expects, but it increases the oxidative stress and free radical damage to the neurons.

Vitamins C and E have been demonstrated to protect neurons even then, at least in Rhesus monkeys :p

Ending the MDMA trip early with an SSRI is supposed to work as well, but the one time I tried that I mis-dosed and took an OD of Xoloft :p

Weirdest / most enjoyable panic attack ever, knew I was safe, felt I was safe, but kept scanning my environment for threats like a lizard on a rock. Had to leave the club and take a walk for half an hour.

Gave me insights into the highly-modular architecture of the human brain, but not sure I'd recommend it.

Raw JSON

{
  "kind": 1,
  "id": "0000508591ef5896b14c2898b03adb8754581dc3139a84bdf6714afe39914512",
  "pubkey": "dae0aff870620203370785a25cd1e90cd6e787d9eec0708636cda97d5bc0cec4",
  "created_at": 1774588516,
  "tags": [
    [
      "e",
      "f7139e0c20d90ce48b429670d77388a8b0c91560206d7b569b71f5ae8dbbb0aa",
      "wss://nos.lol",
      "root"
    ],
    [
      "p",
      "fcf70a45cfa817eaa813b9ba8a375d713d3169f4a27f3dcac3d49112df67d37e"
    ],
    [
      "nonce",
      "37658",
      "16"
    ]
  ],
  "content": "Dosage and quality control are key, and Prohibition militates against both.\n\nI've had MDMA maybe ten times in my life, never once experienced the crash.\n\nDodgy suppliers mix dopaminergics in with the MDMA because its cheaper and gives the effect the market expects, but it increases the oxidative stress and free radical damage to the neurons. \n\nVitamins C and E have been demonstrated to protect neurons even then, at least in Rhesus monkeys :p\n\nEnding the MDMA trip early with an SSRI is supposed to work as well, but the one time I tried that I mis-dosed and took an OD of Xoloft :p \n\nWeirdest / most enjoyable panic attack ever, knew I was safe, felt I was safe, but kept scanning my environment for threats like a lizard on a rock. Had to leave the club and take a walk for half an hour. \n\nGave me insights into the highly-modular architecture of the human brain, but not sure I'd recommend it.",
  "sig": "f6cf73c4260f2547e417c4c81346ec4a80641a998403ac878885ca728104d0f30318745e890f72ff456cf065a75e304eb671cd4a07514ba1051ff47036866740"
}